Main advantage of deca-durabolin is
good anabolic effect and increased protein synthesis in muscle cells, which
leads to superb muscle growth. However, protein
building effect will occur in the body only if sufficient amount of calories
and proteins is supplied, otherwise good results cannot be obtained.
Since Nandrolone stores more water in the connective
tissues, it can temporarily ease or even cure existing pain in joints. This
process is called water retention, which is more considerable comparing to
using of injectable testosterones and it also leads to bigger outlook. Therefore,
athletes who complain about pain in the shoulders, elbows, knees, can safely
train with the aid of Deca-Durabolin.
Dosage of 400 mg per week also helps to accelerate
recovery due to moderate androgenic effect of deca.
Dosage and usage
Athletes use Deca-Durabolin
for muscle buildup and during bulking part of preparation for a contest
because Deca promotes protein synthesis although other side
of coin is water retention in the body. The dosage for men lies between 200 -
600 mg per week, the most common option is 400 mg. Scientific studies have
shown that the best results can be achieved with 4 mg per 1 kg (2
mg/pound) of body weight.
At a dosage below 200 mg per week, the
anabolic effects is very weak. 200-600 mg - anabolic effects growth rapidly
with dosage. If dosage exceeds 600 mg / week, anabolic effect is still no
more than effect of 600 mg but side effects start killing all positive
ones, so this dosage is not advisable. 1000mg is not better than 600 mg.
Beginners should
use 200 mg/week, max 400 mg/week.
Inject deca-duraboline
(nandrolone decanoate) in equal dosages twice a week
deep in muscles, preferably buttocks.
Stacking
Deca-Durabolin is an effective steroid,
which not only gives the desired results, but also goes well with other
steroids in order to achieve a more rapid effect.
For
muscle-build purposes deca very well combines with
Dianabol (methandienone) and Testosterone. The
classic Deca / Dianabol combo is for fast and strong gaining of muscle mass.
Most athletes usually take 15 - 40 mg Dianabol per day and 200 - 400 mg Deca
per week. Even faster results can be achieved with 400 mg of Deca / week and
500 mg Sustanon 250 / week.
Enormous gain in strength and muscle size could be
achieved with 400 mg Deca, 500 mg Sustanon 250 / week and 30 mg of Dianabol
/ day.
Professional users can combine deca with
anapolon (anadrol/oxydrol)
instead of dianabol.
A good startup stack is deca (deca durabolin, nandrolone decanoate) 400
mg/week + dianabol (danabol, naposim, methandienone) 40-50 mg/day.
Length of cycle is 8 weeks. Don't forget about anti-estrogen from the week 3
and 1 week after the cycle - tamoxifen or clomid (1 tab ED).
For this cycle we advice you also using LIV-52 for liver protection.
Using anti-estrogen for this cycle is important. Also, it restores natural
test production. Using liv-52 is not absolutely necessary but makes this
cycle completely safe.
For the whole 8 week cycle athlete needs: Deca: 3200mg, Dianabol" ~
2240-2800 mg, Tamoxifen/Clomid: 50 tabs, Liv-52: 1 bottle.
Although Deca-Durabolin is not an optimal steroid when preparing for
competition due to excessive water storage many athletes still achieve good
results during this phase of preparation if they have suficient time to
"dry" afterwards. Alternatively, athlete may switch
from long-acting deca to faster-acting ester
duraboline (nandrolon-phenilpropionate) and thus avoid extra water
retention.
Classic preparatory stack for
contest is following: Deca-Durabolin 400 mg/week,
Winstrol 50 mg/day, Parabolan 228 mg/week
(every ampule contains 76 mg of substance)
, and Anavar (Oxandrolone) 25-30 mg/day (10 mg tabs).
Injectable Nandrolone (Deca-Durabolin) has no negative effect on the
liver even if used for years UNLESS OVERDOSED. It can even be used by persons with liver diseases.
Even deca/dianabol combo negative effect on the liver could be eliminated quickly after
user discontinues dianabol part.
Relatively safe stack is a combination of Deca Durabolin
400 mg/week with Andriol 280mg / day. Both of these
products are liver-friendly. However, PCT is still necessary.
Detection times
If doping tests are expected it is better to refrain
from taking Deca Durabolin because its traces remain in the body for
quite a long time.
In certain cases Nandrolone Decanoate (deca-duraboline) is detectable
for up to 18 months (1 and 1/2 year) although this is an extreme occasion.
Side effects
and PCT (Post Cycle Therapy) with deca
It's not advisable to use
nandrolone for the athletes below 21 y.o. and especially in
prepubescent period because it might be very harmful for their health.
Due
to relatively low androgenic ratio, aromatization (i.e. conversion into
estrogen) with Deca used standalone appears only at a dose of 400 mg per
week, although this does not mean that one should neglect it completely.
Aromatization appears for all steroids with androgenic component and may
result in growing breast (so-called "bitch tits"), female-patter fat deposits, etc., so
it's much better to avoid such side effects by using anti-estrogen (see
below).
Androgen-related side effects are unlikely to appear at dosages up
to 400 mg but still should be considered. They include high blood pressure, blood
clotting, which leads to frequent bleeding from the nose and a long healing
of scratches, as well as increased production of the sebaceous gland and
occasional acne. Some athletes also report headaches and sexual
overstimulation. When very high doses are used over a prolonged period they
can inhibit spermatogenesis. I.e., testes produce less testosterone
because Deca-Durabolin, like almost all steroids, inhibits the release of
gonadotropins from the hypophysis. To prevent this using of clomiphen/tamoxifen
AFTER the cycle is must-do requirement.
Another common side effect is excessive water retention, which is not that
bad in certain occasions, for instance pain in joints, but most athletes
still want to avoid it.
Aromatization and partially water retention could be eliminated by use of
proviron and tamoxifen (zymoplex, novadex, cytotam) or clomiphen. Take 1 tab
of clomiphen/tamoxifen during the cycle, 3 tabs for the first day after it and 2 tabs / ED
(every day) for two-three weeks
afterwards. Proviron should be added in case of "heavy" cycle when action of
tamo/clom is not sufficient.
Female usage
One of classic
female stacks is Deca + Primobolan + winstrol
depot or it's variances Deca+oral primo / Deca+oral winstrol
Deca dosage
up to
100 mg per week is normally quite safe for women. With higher dosages
androgen-related side effects may occur. This is called virilization -
irreversible appearing of deep "men's" voice, increased growth of body hair,
acne, increased libido, clitorishypertrophy.
To
avoid skin problems female athletes may use more fast-acting duraboline (nandrolon-phenilpropionate).
50-100 mg of Duraboline per week could be a good choice for
them who are very sensetive to androgenic side effects.
But in most cases even long-acting Deca 50-100 mg/week is OK and female
athletes may combine it with Anavar 10
mg/ ED (every day). Both compounds, when taken in a low dosage, have only slight
androgenic component so that virilization side effects only rarely occur.
Deca provides substantial muscle growth and Anavar provides measurable
strength gain with very low water retention. Switching from deca to
primobolan in this stack will make cycle even safer but gains will be lower,
too.
Medical
International name: Nandrolone
Group: Anabolic steroid agent
Description of the active substance (INN): Nandrolone
Dosage form: solution for intramuscular injection (oil)
Characteristics:
Anabolic steroid drug. Comparing to testosterone has a higher, prolonged
(3-4 weeks due to using of decanoate ester) anabolic and low androgenic activity.
Causes activation of gene regulators in the cell nucleus by binding to
specific protein receptors on the cell surface of target organs and the
formation of a complex receptor - nandrolone, which provides transport across
the cell membrane of the last in hyaloplasm where it crosses the nuclear
membrane into the cell nucleus.
Androgenic effect stimulates the synthesis of nucleic acids (DNA,
RNA) and structural proteins (which is associated with increased absorption
in the body of nitrogen, phosphorus, sulfur, and K +), amplification of
tissue respiration and oxidative phosphorylation in skeletal muscle with
accumulation macroergs (ATP, creatine phosphate) .
Promotes fixation of Ca2 + in the bones, increase bone mass when treating osteoporosis,
increases appetite, and muscle mass with a corresponding increase in
body weight.
Accelerates the growth of male sex organs and development of secondary
male sexual characteristics. Stimulates the secretory activity of
androgen glands - male sex glands (activation process of spermatogenesis,
sebaceous glands; in large doses causes suppression of Leydig cells and reduces
the synthesis of endogenous sex hormones due to the oppression pituitary FSH
and LH (negative feedback).
Anabolic effect is manifested activation of reparative processes in the
epithelium (blanket and glandular), bone and muscle tissues by stimulating
protein synthesis and structural components of cells.
Increases absorption of amino acids from the small intestine (compared to a
diet rich in protein), creating a positive nitrogen balance.
Stimulates the production of erythropoietin and activates anabolic
processes in bone marrow, treats anemia along with Fe (iron) supplements.
Violates the synthesis of vitamin K-dependent plasma coagulation factors
(II, V, VII, X) in the liver, changes the plasma lipid profile (cholesterol
concentration increases and decreases - HDL) cholesterol, increases the
reabsorption of Na + and water in the kidneys, contributing to the formation
of edema.
It is effective in women with disseminated breast carcinoma.
Uses:
Diabetic retinopathy, progressive muscular dystrophy, infantile progressive
atrophy syndrome (Verdniga-Hoffmann), states characterized by a negative
balance of Ca2 + (senile and postmenopausal osteoporosis, prolonged
treatment with corticosteroids).
Increased catabolic processes, depleting the resources of the body (chronic
infections, extensive surgery, SCS-induced myopathy, dekubital sores,
burns, severe trauma).
Anemia: against hyperazotemia with chronic renal failure, congenital
aplastic anemia, aplastic anemia (with myelofibrosis, mieloskleroze, myeloid
bone marrow aplasia, bone marrow metastases of malignant neoplasms, drug
myelotoxicity and heavy metal salts).
As an aid in cytostatic therapy of cancer (except prostate cancer),
inoperable (metastatic) breast carcinoma in women postmenopauznom period or
after ovariectomy.
Pituitary dwarfism in children and adolescents (as adjuvant therapy in low
therapeutic effect against the appointment of GH).
Contraindications:
Hypersensitivity, prostate cancer, breast cancer (in men), breast cancer
(with metastases in the presence of hypercalcemia), severe hepatic failure,
nephrosis, glomerulonephritis (nephrotic form), hypercalcemia (including
history), pregnancy, prepubescent age.
Caution.
Coronary artery
disease, heart failure, marked atherosclerosis, myocardial infarction
(including history), hypertension, stroke, chronic renal failure, epilepsy,
migraine, diabetes, prostatic hypertrophy, liver failure, lactation (data on
the penetration into breast milk no), children (up to 2 years - the efficacy
and safety have not been established) and old age.
Side effects:
Men and women - the progression of atherosclerosis (increase of
concentration of LDL and decrease HDL cholesterol concentrations), iron
deficiency anemia, peripheral edema, dyspeptic symptoms (epigastric pain,
abdominal pain, nausea, vomiting), abnormal liver function with jaundice,
leukemoid syndrome (leukemia pain in long bones), hypocoagulation with a
tendency to bleed, gepatonecrosis (dark stools, vomiting with blood, headache,
discomfort, respiratory failure), hepatocellular carcinoma, hepatic purpura
(dark urine, fecal discoloration, urticaria, or point makulear hemorrhagic
rash on the skin and mucous membranes, sore throat or sore throat),
cholestatic hepatitis (yellow coloration of sclera and skin, pain in the
right upper quadrant, dark urine, discolored feces), increased secretion of
the sebaceous glands, chills, increased or decreased libido, diarrhea,
feeling overflow in the stomach, bloating, cramps, sleep disturbance.
For women: effects virilism (clitoral enlargement, deepening or
hoarseness, and dis-amenorrhea, hirsutism, acne, steroid, oily skin)
Hypercalcemia (CNS depression, nausea, vomiting, fatigue).
Men: in prepubertal - virilism (acne, penis, priapism, development of
secondary sexual characteristics), idiopathic hyperpigmentation of the skin,
slowing or stopping growth (calcification of the epiphyseal growth zones of
long bones) in the period postpubertatnom - irritation of the bladder
(increased frequency of desires), mammalgia, gynecomastia, priapism,
decreased sexual function, the elderly - hypertrophy and / or carcinoma of
the prostate.
Overdose.
Symptoms: hepatotoxicity. Treatment: gastric lavage, symptomatic therapy
appointment.
Application and dosage:
Intramuscular, an average dose of 50 mg, 1 time every 3-4 weeks. If necessary, increase
to 100 mg. Children: 0.4 mg / kg every 3-4 weeks. Duration of therapy to 12
months, if necessary, may repeat course of therapy after 4 weeks of break.
In the treatment of severe conditions (including breast cancer, refractory
anemia) may require higher doses, determined by comparing the therapeutic
effects and the risks and benefits of therapy. Treatment against the
background of high-protein diet.
When anemia (in conjunction with drugs Fe) - 100-200 mg (for women - 50-100
mg), 1 per week to stimulate anabolic processes - 50-200 mg (women - 50-100
mg), 1 in 1-4 weeks for children 2-13 years - 25-50 mg 1 every 3-4 weeks.
With carcinoma of the breast (nandrolone phenilpropionate) - 50-100 mg 1 time
per week. Duration of treatment - individual.
When anemia in the background hyperazotemia with chronic renal failure and
as an auxiliary drugs against cytostatic therapy is prescribed at a dose of
75 mg. Patients with severe chronic renal failure - 50 mg 1 time per week. V
/ m injection should be deep, preferably in the gluteal muscles.
Cautions:
In the course of treatment requires systematic monitoring of blood
concentrations of Ca2 + (especially in patients with breast cancer and the
presence of metastases in the bone), cholesterol (especially in patients
with concomitant diseases CAS), glucose (diabetes mellitus), hematocrit, Hb,
serum phosphorus, as well as the functional state of the liver.
The treatment must be ensured adequate intake of adequate amounts of
protein, fat, carbohydrates, vitamins and minerals.
If you have menstrual irregularities and / or signs of virilization
treatment should be discontinued.
Suppresses lactation.
The use of anabolic steroids to stimulate athletic qualities can cause
serious health problems and is unacceptable.
The cold solution may become cloudy, in this case must be heated to dissolve
the crystals vial before use.
Used with caution in children and adolescents due to the risk of premature
closure of epiphyseal growth zones, early puberty in males and virilization
in women. The acceleration of epiphyseal growth of long bones can be
observed in children both during treatment and after 6 months after stopping
treatment.
To monitor the status of the epiphyseal growth zones of long bones in
children and adolescents is recommended radiographic study of every 6
months.
It should be noted that the use of anabolic steroids in elderly patients may
contribute to the development of prostatic hyperplasia.
The feasibility of using anabolic steroids in osteoporosis is unclear
(unproven efficacy and high risk of serious side effects.)
Interaction:
Enhances the effects of indirect anticoagulants, insulin and oral
hypoglycemic drugs, antiplatelet agents.
Attenuates the effects of growth hormone and its derivatives (accelerates
the mineralization of the epiphyseal growth zones of long bones).
GCS and ISS, corticotropin, Na +-containing drugs and foods rich in Na +,
increase (each) fluid retention, increasing the risk of edema, increase the
severity of acne.
Simultaneous with the appointment of hepatotoxic drugs increases the risk of
liver problems.
